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| 28 Jan 08, 4:43 PM Need2BTold 4 yrs  |
Yes thats exactly what I was getting at.. Warfarin is usually prescribed if you have had clotting episodes or if you have had a new heart valve fitted to prevent clotting around that new valve and keep the blood flow good. To take warfarin willy nilly would be dangerous as I said. Thin the blood too much and yes you could set yourself up for a bleed anywhere in the body. Also, there may be a set back as your blood regulates itself to. Aspirin however can cause bleeds to your stomach if taken in high doses and dont quote me on this but I think aspirin can take a little while to settle and work in your system effectively. Aspirin cannot be taken by asthmatics for instance and cannot be taken with several other medicines.. Think very carefully if you want to persue this avenue just to get your thrills.. Needy | ||
| 28 Jan 08, 4:56 PM masterofpuppets UK(MK), 5 yrs  |
Hi. I was in hospital recently, being treated for a serious illness.
After my last operation, I was given regular injections of Heparin, which I undertsand is a Warfarin derivative.
I have only now been given the all clear. Being a bit of a masochist, I didn't play at all for almost 18 months.
I played hard twice in the space of a week, recently, and am glad to say that it doesn't seem to have affected my limits or capacity to endure pain. UNFORTUNATELY ( lol ).
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| 28 Jan 08, 4:59 PM Need2BTold 4 yrs |
Hello MasterofPuppets Heparin is designed to dissolve any clots that may form or have formed. You can have operations etc with no trouble whilst taking heparin and is often used to prevent any clots or DVT'S forming. Warfarin prevents the clotting factor in your blood from working totally depending on the level that your INR is set at which is usually between 2.5 and 3.5. By the way I am not currently taking warfarin. | ||
| 28 Jan 08, 5:40 PM Badg1Vo UK(B), 6 yrs |
Not quite.
Also not quite, but closer to correct than your last wrong statement Heparin also prevents the blood from clotting, but by a different mechanism than warfarin. Heparin's advantage is its disadvantage ... rapid onset, rapid offset compared with warfarin, and the fact that for heparin (rather than 'fractionated heparin' or 'low molecular weight heparin') - heparin is given by i.v. infusion. In the same way that INR is an (International Normalised) Ratio of how long someone's clotting time is extended by the warfarin compared to normal, there is an equivalent APTT Ratio (APTTR) that can be measured for heparin. Say, if someone needs an operation during which they might bleed lots and they are on warfarin - the warfarin level takes a while to build up or decrease. If it is critical they are on anti-coagulants, they will be admitted to hospital and put on heparin and their warfarin stopped. Their heparin based anti-coagulation can be adjusted up (by the APPTR) as their warfarin effect (measured by INR) decreases. Their heparin can then be stopped or reduced when it is time for surgery, as the heparin will wear off a lot quicker than the warfarin does. Once surgery is over, the heparin can be restarted or adjusted back up, and the warfarin restarted. The heparin will achieve effect quicker, giving controllability and safety while waiting for the warfarin to come back up to giving the desired INR. So, a) An APPTR of 8 doesn't mean a safer operation than an INR of 8 ... just that the APPTR will fall quicker than the INR will. b) Both heparin and warfarin will reduce the risks of clots forming, or shift the balance of clot formation vs clot resolution in favour of clots resolving. The target INR (APTTR too?) will depend on the nature and severity of why anti-coagulation is needed. Cheers, Badg1. Edited 28 Jan 08, 5:52 PM by Badg1Vo | ||
| 28 Jan 08, 5:43 PM silvercat UK, 10 yrs |
And I bet some of you didn't know that horses with navicular disease sometimes get prescribed Warfarin!!! My horse used to take it very easily in the middle of a Polo mint. On a more serious note my mother takes Warfarin after a stroke. Not good when she cuts herself or has a nose bleed as she takes longer to clot than people not on meds. | ||
| 28 Jan 08, 5:47 PM Badg1Vo UK(B), 6 yrs |
Aspirin can cause severe asthma attacks in some asthmatics. If you have asthma and you have never had aspirin or medicines of the same group - then please don't try. However, many asthmatics already know they CAN take aspirin safely without it affecting their asthma - these people are why to say "Aspirin cannot be taken by asthmatics" isn't true - it can be taken by some, it can't be safely taken by others. Aspirin and warfarin together are no-no's - except on medical advice. Cheers, Badg1. | ||
| 28 Jan 08, 5:54 PM Trilux UK, 4 yrs |
Yes, once - but not any more. Warfarin-resistant rats are now commonplace so pest-controllers tend to use a super-warfarin like Brodifacoum because it's a much sneakier poison with a much longer biological half-life.
Some of the most powerful anticoagulants are viper venoms, though obviously, you don't want to mess with those. For one thing, their venom is also markedly cytotoxic. Put another way, if you get bitten on the hand there's a good chance you'll lose some fingers. http://www.bartleby.com/106/173.html Edited 28 Jan 08, 6:02 PM by Trilux | ||
| 28 Jan 08, 5:57 PM mini_velvet UK(EH), 6 yrs |
I take heparin when I'm pregnant, and aspirin, but I wouldn't be playing then anyway. And the day came when the risk to remain tight in a bud was more painful than the risk it took to blossom. | ||
| 28 Jan 08, 6:19 PM Need2BTold 4 yrs |
Ty for the detailed correction badg1 much appreciated...
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